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Nature 453, 995-996 (19 June 2008) | doi:10.1038/453995a; Published online 18 June 2008
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Cancer: Deconstructing oncogenesis
Abstract
Transformation of normal cells into cancer cells entails concerted changes in the expression of many genes. Identifying which of those genes are crucial will provide insight into the mechanisms underlying malignancy.
Multiple genetic alterations pave the way for transformation of a normal cell into a cancer cell. At the core of this process are oncogenic (cancer-causing) mutations in critical genes, which lead to sustained proliferative drive and desensitization of the cell to cues that normally inhibit growth or promote cell death1.
- Ji Luo and Stephen J. Elledge are in the Howard Hughes Medical Institute and the Department of Genetics, Center for Genetics and Genomics, Harvard Medical School, Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
Email: selledge@genetics.med.harvard.edu
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