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Review
Nature 453, 869-878 (12 June 2008) | doi:10.1038/nature06976
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Lecturer / Senior Lecturer in Climate Change and Biodiversity
- University Of Queensland, Australia
- Brisbane, Queensland, Australia
Sensory Scientist
- Philip Morris International (PMI)
- Neuchatel, Switzerland
What we can do and what we cannot do with fMRI
Nikos K. Logothetis1
Abstract
Functional magnetic resonance imaging (fMRI) is currently the mainstay of neuroimaging in cognitive neuroscience. Advances in scanner technology, image acquisition protocols, experimental design, and analysis methods promise to push forward fMRI from mere cartography to the true study of brain organization. However, fundamental questions concerning the interpretation of fMRI data abound, as the conclusions drawn often ignore the actual limitations of the methodology. Here I give an overview of the current state of fMRI, and draw on neuroimaging and physiological data to present the current understanding of the haemodynamic signals and the constraints they impose on neuroimaging data interpretation.
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