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Nature 452, 824-825 (17 April 2008) | doi:10.1038/452824a; Published online 16 April 2008
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Systems biology: Genome rewired
Matthew R. Bennett1 & Jeff Hasty1
Abstract
Within a genome, genes are connected to each other through a complex network of interactions. One way to assess how robust and evolvable such genomic networks are is to introduce new links between unrelated genes.
Change in the genetic code is the driving force of classical evolution. Typically, it is thought that mutations in single nucleotides within the DNA sequence ensure such change, but other random alterations such as deletion, duplication and recombination of gene sequences can also occur.
- Matthew R. Bennett and Jeff Hasty are in the Department of Bioengineering and Institute for Nonlinear Science, University of California, San Diego, La Jolla, California 92093-0412, USA.
Email: hasty@bioeng.ucsd.edu
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