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Nature 452, 822-823 (17 April 2008) | doi:10.1038/452822a; Published online 16 April 2008

Biophysics: The sweetest candy for the virus

Andreas O. Frank1 & Horst Kessler1

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For some viruses, the first step in infecting cells is to latch onto sugars on the cell membrane. The chemical basis of this virus-host recognition process has been identified using an NMR spectroscopic technique.

A few weeks ago, many of our friends suffered from 'winter vomiting disease', a form of gastroenteritis that swept epidemically across Germany. This unpleasant disease is caused by the highly contagious norovirus, a member of the Caliciviridae family of RNA viruses.

  1. Andreas O. Frank and Horst Kessler are in the Center of Integrated Protein Science, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany.
    Email: andreas.frank@ch.tum.de
    Email: horst.kessler@ch.tum.de