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Nature 452, 571-579 (3 April 2008) | doi:10.1038/nature06916; Published online 2 April 2008
Open Innovation Challenges
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Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
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Single-cell Analysis Platform
This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is...
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One Postdoctoral Position at Centre for Research in Agricultural Genomics
- The Centre for Research Agricultural Genomics Consorcio CSIC-IRTA-UAB
- Barcelona Spain
Four Postdoctoral Fellow Positions – Synchrotron Medical Imaging
- CIHR Team in Synchrotron Medical Imaging
- Saskatchewan, Canada
Review Article Mining the plasma proteome for cancer biomarkers
Samir M. Hanash1, Sharon J. Pitteri1 & Vitor M. Faca1
Abstract
Systematic searches for plasma proteins that are biological indicators, or biomarkers, for cancer are underway. The difficulties caused by the complexity of biological-fluid proteomes and tissue proteomes (which contribute proteins to plasma) and by the extensive heterogeneity among diseases, subjects and levels of sample procurement are gradually being overcome. This is being achieved through rigorous experimental design and in-depth quantitative studies. The expected outcome is the development of panels of biomarkers that will allow early detection of cancer and prediction of the probable response to therapy. Achieving these objectives requires high-quality specimens with well-matched controls, reagent resources, and an efficient process to confirm discoveries through independent validation studies.
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Biomarker Development, Commercialization, and Regulation: Individualization of Medicine Lost in TranslationClinical Pharmacology & Therapeutics News and Views
Biomarker validation by targeted mass spectrometryNature Biotechnology News and Views (01 Jul 2009)
