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Nature 452, 571-579 (3 April 2008) | doi:10.1038/nature06916; Published online 2 April 2008
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Postdoctoral Fellow - Computational Genomics - Team 78 – Ref: 80464
- Wellcome Trust Sanger Institute
- Hinxton, Cambridgeshire CB10 1, UK
Basic Science Medical Educators
- Texas Tech University Health Sciences Center
- El Paso, Texas, USA
Review Article Mining the plasma proteome for cancer biomarkers
Samir M. Hanash1, Sharon J. Pitteri1 & Vitor M. Faca1
Abstract
Systematic searches for plasma proteins that are biological indicators, or biomarkers, for cancer are underway. The difficulties caused by the complexity of biological-fluid proteomes and tissue proteomes (which contribute proteins to plasma) and by the extensive heterogeneity among diseases, subjects and levels of sample procurement are gradually being overcome. This is being achieved through rigorous experimental design and in-depth quantitative studies. The expected outcome is the development of panels of biomarkers that will allow early detection of cancer and prediction of the probable response to therapy. Achieving these objectives requires high-quality specimens with well-matched controls, reagent resources, and an efficient process to confirm discoveries through independent validation studies.
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