Table of contents
Volume 451 Number 7182 pp1029-1138
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Editorials
A new Silver Age? p1029
The Spanish government has doubled research spending in four years. The next government must create the legal structures to ensure that this money is wisely spent.
doi:10.1038/4511029a
Lone Star vs creationism p1030
The battle against anti-scientific literalism continues. Next stop Texas.
doi:10.1038/4511030a
Time to take control p1030
With money now flowing in, the fight against malaria must shift from advocacy to getting results.
doi:10.1038/4511030b
See also: Editor's summary
News
Animal-rights activists invade Europe p1034
Experts fear extremists may be travelling from Britain.
Geoff Brumfiel
doi:10.1038/4511034a
Acclaimed photo was faked p1034
Chinese prizewinner merged two images.
Jane Qiu
doi:10.1038/4511034b
Revamp for NIH grants p1035
US funding body slims down application process.
Meredith Wadman
doi:10.1038/4511035a
The aftermath of independence p1036
The formerly Serbian province of Kosovo unilaterally declared its independence on 17 February. Some 10,000 Serbian students and academics live in enclaves in the ethnically divided city of Kosovska Mitrovica in the north of the new country dominated by Kosovar Albanians. Endocrinologist Aleksandar Jovanovic, vice-rector for science and international relations at the University of Mitrovica, discusses recent events.
Quirin Schiermeier
doi:10.1038/4511036a
Neglected diseases get vaccine research boost p1037
Drug company opens non-profit centre in Italy.
Alison Abbott
doi:10.1038/4511037a
Snapshot: 'Doomsday vault' opens p1037
Michael Hopkin
doi:10.1038/4511037b
Sidelines p1037
Scribbles on the margins of science.
doi:10.1038/4511037c
Iran refuses to cooperate with atomic agency p1038
IAEA report highlights unanswered questions.
Declan Butler
doi:10.1038/4511038a
First chapter of book of life goes live p1038
Online encyclopedia launches first data.
Emma Marris
doi:10.1038/4511038b
Meat meter measures marbled muscles p1039
Scientists devise way to measure tastiness of meat.
David Cyranoski
doi:10.1038/4511039a
English grants under review p1039
Funding agency ditches peer review in favour of metrics.
Daniel Cressey
doi:10.1038/4511039b
Strict ordering slashes tarmac time p1040
Physicist identifies fastest way to board aircraft.
Philip Ball
doi:10.1038/4511040a
UCLA wins restraining order against activists p1041
doi:10.1038/4511041a
Indonesia relents over bird-flu sample release p1041
doi:10.1038/4511041b
Biosafety lapses cost Texas A&M $1 million p1041
doi:10.1038/4511041c
US missile destroys toxic tank on spy satellite p1041
doi:10.1038/4511041d
Florida adopts teaching of evolution in its schools p1041
doi:10.1038/4511041e
Grey wolf no longer in danger, says US government p1041
doi:10.1038/4511041f
News Features
Malaria: The end of the beginning p1042
After decades of work, a pioneering malaria vaccine may soon reach the final phase of clinical trials. In the first of two features on efforts against malaria, Brendan Maher reports on a vaccine that is far from perfect — but which may provide new direction and save thousands of lives.
doi:10.1038/4511042a
Malaria: The big push p1047
Zambia, with help from partners around the world, is stepping up its battle against malaria. Michael Hopkin reports from the rural front line.
doi:10.1038/4511047a
Correspondence
Political debate: science will be the loser p1050
Daniel Sarewitz
doi:10.1038/4511050a
Political debate: it is a risk, but one that's worth taking p1050
Neal Lane
doi:10.1038/4511050b
Government subsidized by academia on conservation p1050
Philip Wheeler
doi:10.1038/4511050c
Celebrations for Darwin downplay Wallace's role p1050
George W. Beccaloni & Vincent S. Smith
doi:10.1038/4511050d
Commentary
The billion-dollar malaria moment p1051
For years the global malaria effort has been asking for more resources. Now the field needs to figure out a systematic strategy for spending the money effectively, says Mark Grabowsky.
doi:10.1038/4511051a
See also: Editor's summary
Books and Arts
Pest friends in the Cretaceous p1053
Fossils preserved in amber hint at surprising links between dinosaurs and their insect contemporaries.
Karen Chin reviews What Bugged the Dinosaurs? Insects, Disease, and Death in the Cretaceous by George Poinar, Jr & Roberta Poinar
doi:10.1038/4511053a
Exhibition: Shots of Silicon Valley p1054
Fred Turner reviews Gabriele Basilico: From San Francisco to Silicon Valley
doi:10.1038/4511054a
Fly image wins photo prize p1054
Joanne Baker reviews the winning image in the photographic competition that forms part of celebrations marking the 200th anniversary of the Royal Netherlands Academy of Arts and Sciences
doi:10.1038/4511054b
Biopiracy started with a bounce p1055
Michael Gollin reviews The Thief at the End of the World: Rubber, Power, and the Seeds of Empire by Joe Jackson
doi:10.1038/4511055a
A feverish imagination p1056
Martin Kemp reviews the poems, plays and novels that punctuated the life of Ronald Ross
doi:10.1038/4511056a
See also: Editor's summary
Hidden treasures: Eise Eisinga Planetarium p1057
The world's oldest functioning planetarium was built by an eighteenth-century wool-comber in the Netherlands. Alison Abbot reports, in the second of her monthly series on small museums
Alison Abbot
doi:10.1038/4511057a
See also: Editor's summary
Essay
When authorship met authenticity p1058
As counterfeit drugs abound, Adrian Johns recalls how medical patenting was created in the seventeenth century to secure trust across growing international trade networks by quashing fakes.
Adrian Johns
doi:10.1038/4511058a
See also: Editor's summary
News and Views
Palaeoclimate: The rhythm of the rains p1061
Deposits in a Chinese cave tell the story of the region's climate stretching back more than 200,000 years, well past the last interglacial warm period — an invaluable resource for understanding the Asian monsoon.
Jonathan Overpeck & Julia Cole
doi:10.1038/4511061a
See also: Editor's summary
50 & 100 Years Ago p1062
doi:10.1038/4511062a
Biotechnology: A hold on plant meiosis p1063
The process of meiosis involves genetic shuffling that dilutes the desirable traits of sexually reproducing crops. Identification of a mutation in which shuffling does not occur is a step forward for plant breeders.
Peter J. van Dijk
doi:10.1038/4511063a
See also: Editor's summary
History of science: Quinine steps back in time p1065
Chemists have long memories. The claim, dating back to 1918, that a crucial step in a synthesis of quinine had been carried out has been validated experimentally, closing a chapter in this fascinating story.
Philip Ball
doi:10.1038/4511065a
See also: Editor's summary
Cancer: Crossing over to drug resistance p1066
Certain cancers stem from mutations that prevent a cell from repairing its damaged DNA efficiently. But antitumour chemotherapy that exploits that repair defect can in turn be nullified by counter-mutation.
David M. Livingston & Daniel P. Silver
doi:10.1038/4511066a
See also: Editor's summary
Environmental economics: To the rich man the spoils p1067
Global economic growth during the past century has lifted many into lives of unprecedented luxury. The cost has been the degradation of vital ecosystems — a cost borne disproportionately by the world's poor.
R. Kerry Turner & Brendan Fisher
doi:10.1038/4511067a
Brief Communications Arising
Do animal personalities emerge? pE8
François Massol & Pierre-André Crochet
doi:10.1038/nature06743
First paragraph | Full Text | PDF (333K)
Wolf et al. reply pE9
Max Wolf, G. Sander van Doorn, Olof Leimar & Franz J. Weissing
doi:10.1038/nature06744
First paragraph | Full Text | PDF (333K)
Review
Autophagy fights disease through cellular self-digestion p1069
Noboru Mizushima, Beth Levine, Ana Maria Cuervo & Daniel J. Klionsky
doi:10.1038/nature06639
First paragraph | Full Text | PDF (3,784K)
See also: Editor's summary
Article
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets p1076
May H. Han, Sun-Il Hwang, Dolly B. Roy, Deborah H. Lundgren, Jordan V. Price, Shalina S. Ousman, Guy Haskin Fernald, Bruce Gerlitz, William H. Robinson, Sergio E. Baranzini, Brian W. Grinnell, Cedric S. Raine, Raymond A. Sobel, David K. Han & Lawrence Steinman
doi:10.1038/nature06559
Abstract | Full Text | PDF (732K) | Supplementary information
See also: Editor's summary
Letters
A minimum column density of 1 g cm-2 for massive star formation p1082
Mark R. Krumholz & Christopher F. McKee
doi:10.1038/nature06620
First paragraph | Full Text | PDF (242K) | Supplementary information
See also: Editor's summary
Designing metallic glass matrix composites with high toughness and tensile ductility p1085
Douglas C. Hofmann, Jin-Yoo Suh, Aaron Wiest, Gang Duan, Mary-Laura Lind, Marios D. Demetriou & William L. Johnson
doi:10.1038/nature06598
First paragraph | Full Text | PDF (4,910K) | Supplementary information
See also: Editor's summary
Millennial- and orbital-scale changes in the East Asian monsoon over the past 224,000 years p1090
Yongjin Wang, Hai Cheng, R. Lawrence Edwards, Xinggong Kong, Xiaohua Shao, Shitao Chen, Jiangyin Wu, Xiouyang Jiang, Xianfeng Wang & Zhisheng An
doi:10.1038/nature06692
First paragraph | Full Text | PDF (244K) | Supplementary information
See also: Editor's summary | News and Views by Overpeck & Cole
Arc-parallel flow in the mantle wedge beneath Costa Rica and Nicaragua p1094
Kaj Hoernle, David L. Abt, Karen M. Fischer, Holly Nichols, Folkmar Hauff, Geoffrey A. Abers, Paul van den Bogaard, Ken Heydolph, Guillermo Alvarado, Marino Protti & Wilfried Strauch
doi:10.1038/nature06550
First paragraph | Full Text | PDF (955K) | Supplementary information
Scaling laws of marine predator search behaviour p1098
David W. Sims, Emily J. Southall, Nicolas E. Humphries, Graeme C. Hays, Corey J. A. Bradshaw, Jonathan W. Pitchford, Alex James, Mohammed Z. Ahmed, Andrew S. Brierley, Mark A. Hindell, David Morritt, Michael K. Musyl, David Righton, Emily L. C. Shepard, Victoria J. Wearmouth, Rory P. Wilson, Matthew J. Witt & Julian D. Metcalfe
doi:10.1038/nature06518
First paragraph | Full Text | PDF (324K) | Supplementary information
See also: Editor's summary
Selection overrides gene flow to break down maladaptive mimicry p1103
George R. Harper Jr & David W. Pfennig
doi:10.1038/nature06532
First paragraph | Full Text | PDF (573K) | Supplementary information
See also: Editor's summary
Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae p1107
Lorenzo A. Santorelli, Christopher R. L. Thompson, Elizabeth Villegas, Jessica Svetz, Christopher Dinh, Anup Parikh, Richard Sucgang, Adam Kuspa, Joan E. Strassmann, David C. Queller & Gad Shaulsky
doi:10.1038/nature06558
First paragraph | Full Text | PDF (346K) | Supplementary information
See also: Editor's summary
Resistance to therapy caused by intragenic deletion in BRCA2 p1111
Stacey L. Edwards, Rachel Brough, Christopher J. Lord, Rachael Natrajan, Radost Vatcheva, Douglas A. Levine, Jeff Boyd, Jorge S. Reis-Filho & Alan Ashworth
doi:10.1038/nature06548
First paragraph | Full Text | PDF (795K) | Supplementary information
See also: Editor's summary | News and Views by Livingston & Silver
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers p1116
Wataru Sakai, Elizabeth M. Swisher, Beth Y. Karlan, Mukesh K. Agarwal, Jake Higgins, Cynthia Friedman, Emily Villegas, Céline Jacquemont, Daniel J. Farrugia, Fergus J. Couch, Nicole Urban & Toshiyasu Taniguchi
doi:10.1038/nature06633
First paragraph | Full Text | PDF (604K) | Supplementary information
See also: Editor's summary | News and Views by Livingston & Silver
Gamete formation without meiosis in Arabidopsis p1121
Maruthachalam Ravi, Mohan P. A. Marimuthu & Imran Siddiqi
doi:10.1038/nature06557
First paragraph | Full Text | PDF (619K) | Supplementary information
See also: Editor's summary | News and Views by van Dijk
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223 p1125
Jonathan B. Johnnidis, Marian H. Harris, Robert T. Wheeler, Sandra Stehling-Sun, Michael H. Lam, Oktay Kirak, Thijn R. Brummelkamp, Mark D. Fleming & Fernando D. Camargo
doi:10.1038/nature06607
First paragraph | Full Text | PDF (774K) | Supplementary information
Backbone structure of the infectious 
15 virus capsid revealed by electron cryomicroscopy p1130
Wen Jiang, Matthew L. Baker, Joanita Jakana, Peter R. Weigele, Jonathan King & Wah Chiu
doi:10.1038/nature06665
PDB code
3D view
First paragraph | Full Text | PDF (1,309K) | Supplementary information
Naturejobs
ProspectProspects p1135
Is science really undergoing globalization?
Gene Russo
doi:10.1038/nj7182-1135a
Career View
Felipe Pereira, distinguished professor, School of Energy Resources and Department of Mathematics, University of Wyoming, Laramie p1136
Energy demand brings Brazilian mathematician to Wyoming.
Virginia Gewin
doi:10.1038/nj7182-1136a
Neuroscience in the developing world p1136
Neuroscience training in Argentina, by any means necessary.
Paul Smaglik
doi:10.1038/nj7182-1136b
Role models p1136
My peers are my mentors.
Amanda Goh
doi:10.1038/nj7182-1136c