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News and Views
Nature 451, 777-778 (14 February 2008) | doi:10.1038/451777a; Published online 13 February 2008
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Organic Chemistry
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Senior Researcher in theoretical chemistry / physics
- Italian Institute of Technology
- Lecce, Italy
Molecular biology: Cohesin branches out
Frank Uhlmann1
Abstract
The cohesin complex — best known for its role in cell division — does not rest between divisions, and instead participates in regulating gene expression. How it does this is only now becoming clear.
Cohesin is one of the large, ring-shaped protein complexes that constitute a substantial fraction of the chromosomal proteins in nucleated cells. It acts as the chromosomal 'glue', and is thought to encircle and so trap pairs of replicated chromosomes, known as sister chromatids.
- Frank Uhlmann is in the Chromosome Segregation Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Email: frank.uhlmann@cancer.org.uk
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