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News and Views
Nature 451, 777-778 (14 February 2008) | doi:10.1038/451777a; Published online 13 February 2008
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Dermapathologist
- Indiana University School of Medicine
- Indiana, USA
PhD - Helmholtz International Graduate School for Infection Research
- Helmholtz-Zentrum fur Infektionsforschung
- Braunschweig Germany
Molecular biology: Cohesin branches out
Frank Uhlmann1
Abstract
The cohesin complex — best known for its role in cell division — does not rest between divisions, and instead participates in regulating gene expression. How it does this is only now becoming clear.
Cohesin is one of the large, ring-shaped protein complexes that constitute a substantial fraction of the chromosomal proteins in nucleated cells. It acts as the chromosomal 'glue', and is thought to encircle and so trap pairs of replicated chromosomes, known as sister chromatids.
- Frank Uhlmann is in the Chromosome Segregation Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Email: frank.uhlmann@cancer.org.uk
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