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Nature 451, 638-639 (7 February 2008) | doi:10.1038/451638a; Published online 6 February 2008

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Neuropathology: Alzheimer's in real time

Eliezer Masliah1

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A hallmark of Alzheimer's disease is the presence in the brain of protein deposits, or plaques, which are thought to form over a long period. But studies in mice suggest that the plaques can grow overnight.

Alzheimer's disease is the commonest neurodegenerative disorder in ageing human populations. It is characterized by memory loss and behavioural alterations in its early stages, and by severe cognitive impairment and dementia later on.

  1. Eliezer Masliah is in the Department of Neurosciences and Pathology, University of California, San Diego, 9500 Gilman Drive, San Diego, California 92093, USA.
    Email: emasliah@ucsd.edu

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