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Nature 450, 1117-1120 (13 December 2007) | doi:10.1038/4501117a; Published online 12 December 2007

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Small RNAs: Delivering the future

Nathan Blow1

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Drugs to treat diseases from cancer to AIDS could soon rely on short strands of RNA for their effects. But scientists must first work out how to navigate these fragments around the body. Nathan Blow reports.

The remarkable ability of short sequences of synthetic RNA to interfere with messenger RNA and thereby silence the activity of specific genes has proved incredibly helpful to geneticists wrestling with genetic function. And the push to harness this RNA interference (RNAi) for therapeutic use is now beginning to make headway.

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