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Nature 450, E12-E14 (22 November 2007) | doi:10.1038/nature06456; Received 9 October 2007; Accepted 6 November 2007; Published online 14 November 2007

There is a Corrigendum (21 February 2008) associated with this document.

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Genotyping of Rhesus SCNT pluripotent stem cell lines

David S. Cram1, Bi Song1 & Alan O. Trounson1

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Arising from: J. A. Byrne et al. Nature 450, doi: 10.1038/nature06357 (2007)

Somatic cell nuclear transfer (SCNT) into enucleated oocytes has emerged as a technique that can be used to derive mouse embryonic stem cell lines with defined genotypes. In this issue Byrne et al.1 report the derivation of two SCNT Rhesus macaca male stem cell lines designated CRES-1 and CRES-2. Molecular studies detailed in their paper provides supporting evidence that the chromosome complement of CRES-1 and CRES-2 was genetically identical to the male cell donor nucleus and that the mitochondrial DNA originated from different recipient oocytes. In this validation paper, we independently confirm that both stem cell lines were indeed derived by SCNT.

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