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Nature 450, 180-181 (8 November 2007) | doi:10.1038/450180a; Published online 7 November 2007

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Developmental biology: The power of blood

Paige Snider1 & Simon J. Conway1

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Compared with the masterpiece crafted by nature, even Leonardo da Vinci's anatomical drawings of the cardiovascular system seem primitive. In creating this system, nature seems to use blood flow as its paintbrush.

More than a century ago, Thoma noted1 that blood vessels carrying a high volume enlarge, whereas those with low flow regress. Since then, significant evidence has accumulated to suggest that the mechanical force created by blood flow affects gene expression in the developing embryo2, 3.

  1. Paige Snider and Simon J. Conway are in the Cardiovascular Development Group, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA.
    Email: siconway@iupui.edu

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