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Nature 449, 549-550 (4 October 2007) | doi:10.1038/449549a; Published online 3 October 2007

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Development: Inflationary pressures

David Bryant1 & Keith Mostov1

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Blowing up a balloon seems straightforward: pump in gas and let the changing air pressure do the rest. But when it comes to blowing up nature's own balloons — lung airways — things are a little more complicated.

The lung consists of an elaborate network of branching tubes; the tubes themselves are made of a layer of epithelial cells wrapped around a hollow, air-filled core, much like the thin rubber of a balloon surrounds the air inside. For the tubes to fit together, and for the right amount of gas to pass through them, they must have precisely the correct dimensions.

  1. David Bryant and Keith Mostov are in the Departments of Anatomy, and Biochemistry and Biophysics, University of California, San Francisco, California 94143-2140, USA.
    Email: keith.mostov@ucsf.edu

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