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Nature 449, 549-550 (4 October 2007) | doi:10.1038/449549a; Published online 3 October 2007
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Development: Inflationary pressures
Abstract
Blowing up a balloon seems straightforward: pump in gas and let the changing air pressure do the rest. But when it comes to blowing up nature's own balloons — lung airways — things are a little more complicated.
The lung consists of an elaborate network of branching tubes; the tubes themselves are made of a layer of epithelial cells wrapped around a hollow, air-filled core, much like the thin rubber of a balloon surrounds the air inside. For the tubes to fit together, and for the right amount of gas to pass through them, they must have precisely the correct dimensions.
- David Bryant and Keith Mostov are in the Departments of Anatomy, and Biochemistry and Biophysics, University of California, San Francisco, California 94143-2140, USA.
Email: keith.mostov@ucsf.edu
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