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Nature 448, 1001-1002 (30 August 2007) | doi:10.1038/4481001a; Published online 29 August 2007

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Molecular biology: Damage control

Claus M. Azzalin1 & Joachim Lingner1

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The chemical composition of normal DNA at the end of chromosomes does not differ from that of damaged and broken DNA within chromosomes. New findings hint at how the DNA-repair machinery distinguishes the two.

The maintenance of genome integrity is crucial for the survival of every organism. So even a single break along a chromosome triggers a molecular signalling cascade that leads to an appropriate DNA-damage response (DDR).

  1. Claus M. Azzalin and Joachim Lingner are at the Institut Suisse de Recherche Expérimentale sur le Cancer (ISREC), 'Frontiers in Genetics' National Center for Competence in Research, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1066, Epalinges s/Lausanne, Switzerland.
    Email: joachim.lingner@isrec.ch

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