Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 448, 1001-1002 (30 August 2007) | doi:10.1038/4481001a; Published online 29 August 2007
Open Innovation Challenges
-
Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
-
Single-cell Analysis Platform
This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is...
- More Challenges
- Powered by:
nature jobs
Bacterial Geneticist / Microbiologist
- TCG Lifesciences Ltd
- Kolkata India
Postdoctoral Research Fellows
- Northwestern University
- Chicago, Illinois, United States
Molecular biology: Damage control
Claus M. Azzalin1 & Joachim Lingner1
Abstract
The chemical composition of normal DNA at the end of chromosomes does not differ from that of damaged and broken DNA within chromosomes. New findings hint at how the DNA-repair machinery distinguishes the two.
The maintenance of genome integrity is crucial for the survival of every organism. So even a single break along a chromosome triggers a molecular signalling cascade that leads to an appropriate DNA-damage response (DDR).
- Claus M. Azzalin and Joachim Lingner are at the Institut Suisse de Recherche Expérimentale sur le Cancer (ISREC), 'Frontiers in Genetics' National Center for Competence in Research, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1066, Epalinges s/Lausanne, Switzerland.
Email: joachim.lingner@isrec.ch
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1Nature Letters to Editor (30 Aug 2007)
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesisThe EMBO Journal Article (14 Nov 2007)
Telomere protection by mammalian Pot1 requires interaction with Tpp1Nature Structural & Molecular Biology Article (01 Aug 2007)
See all 36 matches for Research