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Nature 448, 883-888 (23 August 2007) | doi:10.1038/nature06031
Integrating molecular and network biology to decode endocytosis
Eva M. Schmid1 & Harvey T. McMahon1
Abstract
The strength of network biology lies in its ability to derive cell biological information without a priori mechanistic or molecular knowledge. It is shown here how a careful understanding of a given biological pathway can refine an interactome approach. This permits the elucidation of additional design principles and of spatio-temporal dynamics behind pathways, and aids in experimental design and interpretation.
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