Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 448, 423-424 (26 July 2007) | doi:10.1038/448423a; Published online 25 July 2007
Open Innovation Challenges
-
Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
- More Challenges
- Powered by:
nature jobs
Assistant Professor
- University of Texas
- Austin TX United States
Assistant Manager-Pharma / CRO-Global Strategic Sourcing
- Varda Biotech
- Mumbai India
Immunology: Sensing the enemy within
Hongbo Chi1 & Richard A. Flavell1
Abstract
Damaged or foreign DNA stimulates immune responses by inducing the production of interferon proteins. New evidence indicates that this response is mediated by a cytosolic DNA sensor known as DAI.
On infection by a pathogen, the immune system rapidly mounts defence mechanisms, characterized by massive production of interferon proteins and other cytokines (immune mediators). This reaction, known as the innate immune response, is mediated by pattern-recognition receptors that detect conserved structures found in a broad range of pathogens.
- Hongbo Chi is in the Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Email: hongbo.chi@stjude.org - Richard A. Flavell is in the Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Email: richard.flavell@yale.edu
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Cytoplasmic double-stranded DNA sensorNature Immunology News and Views (01 Sep 2007)
New DNA-sensing pathway feeds RIG-I with RNANature Immunology News and Views (01 Oct 2009)
See all 8 matches for News And ViewsRESEARCH
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune responseNature Letters to Editor (26 Jul 2007)
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III?transcribed RNA intermediateNature Immunology Article (01 Oct 2009)
See all 22 matches for Research