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Nature 448, 421-422 (26 July 2007) | doi:10.1038/448421a; Published online 25 July 2007
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Associate Professor / Professor ? NCRIS TERN Director
- University Of Queensland, Australia
- Brisbane, Queensland, Australia
Molecular & Human Genetics
- Indian Institute of Chemical Biology
- Kolkata India
Inflammatory disease: Assault on the guardian
Richard M. Ransohoff1
Abstract
In multiple sclerosis, the immune system attacks 'self' tissues. Ten years after the discovery of one target of this autoimmunity, work with mice identifies it as a guardian protein produced in response to inflammation.
On page 474 of this issue, Ousman and her co-workers1 describe how autoimmunity to a protein known as 
B-crystallin (CRYAB) can contribute to inflammatory injury of the central nervous system. They show that autoimmune attack on CRYAB does not directly cause tissue damage.
- Richard M. Ransohoff is in the Neuroinflammation Research Center, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.
Email: ransohr@ccf.org
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