In mice, deletion of the Rab8 protein disrupts organized molecular distribution to membranes of intestinal epithelial cells. Death by starvation follows, exactly as it does in humans with microvillus inclusion disease.
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Lakkaraju, A., Rodriguez-Boulan, E. Caught in the traffic. Nature 448, 266–267 (2007). https://doi.org/10.1038/448266a
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DOI: https://doi.org/10.1038/448266a
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