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Nature 447, 921-922 (21 June 2007) | doi:10.1038/447921a; Published online 20 June 2007
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Tenure-track Faculty Positions
- University of Michigan
- Ann Arbor, Michigan, USA
3 Postdoctoral positions available
- Baylor College of Medicine
- Houston, Texas, USA
Structural biology: ESCRT service
Steven L. Alam1 & Wesley I. Sundquist1
Abstract
The sorting and degradation of cell-surface proteins are essential for cellular homeostasis. The ESCRT-I complex is known to be involved in these events, and new structural findings elucidate its core architecture.
The compartmentalization of cells in higher organisms has brought about the need for reliable trafficking systems to transport cargoes in and out of different membrane-enclosed organelles. The endosomal sorting complex required for transport-I (ESCRT-I), which is evolutionarily conserved from yeast to humans, is one component of the intracellular trafficking machinery.
- Steven L. Alam and Wesley I. Sundquist are in the Department of Biochemistry, University of Utah, 15 North Medical Drive East, Room 4100, Salt Lake City, Utah 84112-5650, USA.
Email: alam@biochem.utah.edu
Email: wes@biochem.utah.edu
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