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Editorials

A clear direction p115

The process established by the Intergovernmental Panel on Climate Change has generated a sound foundation of knowledge on which policy-makers must now build.

doi:10.1038/447115a


Starting at the top p115

Scientific élites retain a severe gender imbalance.

doi:10.1038/447115b


Under the microscope p116

The use of 'black box' techniques carries risks.

doi:10.1038/447116a


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Research Highlights

Research highlights p118

doi:10.1038/447118a


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News

Climate panel offers grounds for optimism p120

The cost of fighting global warming may not be as high as feared.

Michael Hopkin

doi:10.1038/447120a

See also: Editor's summary


A clash of cosmologies p122

Is too much physics bad for astronomy?

Geoff Brumfiel

doi:10.1038/447122a


Snapshot: Ghosts of destruction p123

Satellite images reveal shrimp trawlers' turbulent trails.

doi:10.1038/447123a


Seven-year grant offers immune tolerance a boost p125

NIH gives initiative $220 million.

Erika Check

doi:10.1038/447125a


Sidelines p125

doi:10.1038/447125b


Wind farms' deadly reputation hard to shift p126

Cats far more lethal than turbines.

Emma Marris & Daemon Fairless

doi:10.1038/447126a


Microbe meeting promotes habitat conservation p127

Microorganisms deemed less important than their environment.

Helen Pearson

doi:10.1038/447127a


News in brief p128

doi:10.1038/447128a


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Column

Party of One

Misspent energy p130

US politicians are pushing to create an advanced research agency to tackle the energy challenges the nation faces. David Goldston explores why the current proposition may be ill-prepared for the task.

David Goldston

doi:10.1038/447130a


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Business

Cheap at any price? p131

As AstraZeneca shells out $15 billion for a mid-sized US biotech firm, Heidi Ledford reports on the startling cost of staying in the drugs business.

doi:10.1038/447131a


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News Features

Climate change: Is this what it takes to save the world? p132

Long marginalized as a dubious idea, altering the climate through 'geoengineering' has staged something of a comeback. Oliver Morton reports.

doi:10.1038/447132a

See also: Editor's summary


The good, the bad and the ugly p138

Imaging fluorescent molecules in live cells is revolutionizing cell biology. But a pretty image is not necessarily a good one, and many biologists are learning this the hard way, finds Helen Pearson.

doi:10.1038/447138a

See also: Editor's summary


Chemistry: Teetering on the edge p141

Why do chemists make compounds that could blow up in their faces? Emma Marris finds out... from a safe distance.

doi:10.1038/447141a


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Correspondence

Structured digital abstract makes text mining easy p142

Mark Gerstein, Michael Seringhaus & Stanley Fields

doi:10.1038/447142a


Human reference sequence makes sense of names p142

Douglas L. Crawford

doi:10.1038/447142b


Codes must be updated so that names are known to all p142

Quentin D. Wheeler & Frank T. Krell

doi:10.1038/447142c


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Commentary

A handful of carbon p143

Locking carbon up in soil makes more sense than storing it in plants and trees that eventually decompose, argues Johannes Lehmann. Can this idea work on a large scale?

doi:10.1038/447143a

See also: Editor's summary


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Books and Arts

Plugged into the matrix p145

The rise and potential fall of the US electricity grid.

Paul M. Grant reviews The Grid: A Journey Through the Heart of Our Electrified World by Phillip F. Schewe

doi:10.1038/447145a


The stem-cell story p146

Justine Burley reviews Stem Cell Now: A Brief Introduction to the Coming Medical Revolution by Christopher Thomas Scott and Cell of Cells: The Global Race to Capture and Control the Stem Cell by Cynthia Fox and Stem Cell Wars: Inside Stories from the Frontlines by Eve Herold

doi:10.1038/447146a


Flight of the dinosaur p147

Angela Milner reviews Glorified Dinosaurs: The Origin and Early Evolution of Birds by Luis Chiappe

doi:10.1038/447147a

See also: Editor's summary


Science in culture: Hidden talent p148

An exhibition in London explores the art of blending into the background.

David M. Wilkinson

doi:10.1038/447148a


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Essay

Connections

Kinds of minds p149

Do differences in history, culture and education influence whether scientists focus on pieces and particulars, or make broad connections?

David Knight

doi:10.1038/447149a


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News and Views

Behavioural neuroscience: Down memory lane p151

In mice, two treatments — environmental enrichment and a chemical that regulates gene expression — boost new memory formation and restore the recall of old memories that seemed to have been lost.

J. David Sweatt

doi:10.1038/nature05716

See also: Editor's summary


Organic chemistry: Radical catalysis p152

The domination of metals in catalysis is under threat as organic catalysts gain ground. The latest example may expand chemical reactivity beyond the achievements of traditional metal complexes.

Santanu Mukherjee & Benjamin List

doi:10.1038/447152a


Developmental biology: A chordate with a difference p153

Molecular studies of tunicate development show that genetic programmes for early embryonic patterning can change radically during evolution, without completely disrupting the basic chordate body plan.

Linda Z. Holland

doi:10.1038/447153a


50 & 100 Years Ago p154

doi:10.1038/447154a


Extrasolar planets: Remote climes p155

A distant planet traversing its orbit shows variations in its infrared brightness, providing the first map of its climate. These variations paint a picture of a dynamic world, with efficient redistribution of stellar heat.

Adam Burrows

doi:10.1038/447155a

See also: Editor's summary


Biochemistry: The big catch p156

The availability of short interfering RNAs (siRNAs) to silence gene expression has revolutionized research in molecular cell biology. But these synthetic siRNAs rely on cellular enzymes for their activity.

Christopher R. Trotta

doi:10.1038/447156a


Condensed-matter physics: Let's twist again p157

The spins of a layer of manganese atoms on a tungsten surface form a spiral pattern with a unique turning sense. Such 'chiral magnetic order' might exist in other, similar contexts, and could have many useful applications.

Christian Pfleiderer & Ulrich K. Rös zligler

doi:10.1038/447157a

See also: Editor's summary


Visual perception: A gloss on surface properties p158

Humans perceive the properties of a surface by interpreting visual input. When estimating gloss and lightness, it seems that neural discrimination of simple image statistics plays a large part.

Michael S. Landy

doi:10.1038/nature05714

See also: Editor's summary


Obituary: Ransom Aldrich Myers (1952–2007) p160

Chronicler of declining fish populations.

Daniel Pauly

doi:10.1038/447160a


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Feature

Completing the map of human genetic variation p161

A plan to identify and integrate normal structural variation into the human genome sequence.

The Human Genome Structural Variation Working Group

doi:10.1038/447161a

See also: Editor's summary


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Articles

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences p167

Tarjei S. Mikkelsen, Matthew J. Wakefield, Bronwen Aken, Chris T. Amemiya, Jean L. Chang, Shannon Duke, Manuel Garber, Andrew J. Gentles, Leo Goodstadt, Andreas Heger, Jerzy Jurka, Michael Kamal, Evan Mauceli, Stephen M. J. Searle, Ted Sharpe, Michelle L. Baker, Mark A. Batzer, Panayiotis V. Benos, Katherine Belov, Michele Clamp, April Cook, James Cuff, Radhika Das, Lance Davidow, Janine E. Deakin, Melissa J. Fazzari, Jacob L. Glass, Manfred Grabherr, John M. Greally, Wanjun Gu, Timothy A. Hore, Gavin A. Huttley, Michael Kleber, Randy L. Jirtle, Edda Koina, Jeannie T. Lee, Shaun Mahony, Marco A. Marra, Robert D. Miller, Robert D. Nicholls, Mayumi Oda, Anthony T. Papenfuss, Zuly E. Parra, David D. Pollock, David A. Ray, Jacqueline E. Schein, Terence P. Speed, Katherine Thompson, John L. VandeBerg, Claire M. Wade, Jerilyn A. Walker, Paul D. Waters, Caleb Webber, Jennifer R. Weidman, Xiaohui Xie, Michael C. ZodyBroad Institute Genome Sequencing Platform and Broad Institute Whole Genome Assembly Team and , Jennifer A. Marshall Graves, Chris P. Ponting, Matthew Breen, Paul B. Samollow, Eric S. Lander & Kerstin Lindblad-Toh

doi:10.1038/nature05805

See also: Editor's summary


Recovery of learning and memory is associated with chromatin remodelling p178

Andre Fischer, Farahnaz Sananbenesi, Xinyu Wang, Matthew Dobbin & Li-Huei Tsai

doi:10.1038/nature05772

See also: Editor's summary | News and Views by Sweatt


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Letters

A map of the day–night contrast of the extrasolar planet HD 189733b p183

Heather A. Knutson, David Charbonneau, Lori E. Allen, Jonathan J. Fortney, Eric Agol, Nicolas B. Cowan, Adam P. Showman, Curtis S. Cooper & S. Thomas Megeath

doi:10.1038/nature05782

See also: Editor's summary | News and Views by Burrows


Superconductivity in lithium below 0.4 millikelvin at ambient pressure p187

Juha Tuoriniemi, Kirsi Juntunen-Nurmilaukas, Johanna Uusvuori, Elias Pentti, Anssi Salmela & Alexander Sebedash

doi:10.1038/nature05820

See also: Editor's summary


Chiral magnetic order at surfaces driven by inversion asymmetry p190

M. Bode, M. Heide, K. von Bergmann, P. Ferriani, S. Heinze, G. Bihlmayer, A. Kubetzka, O. Pietzsch, S. Blügel & R. Wiesendanger

doi:10.1038/nature05802

See also: Editor's summary | News and Views by Pfleiderer & Rös zligler


Short-circuiting of the overturning circulation in the Antarctic Circumpolar Current p194

Alberto C. Naveira Garabato, David P. Stevens, Andrew J. Watson & Wolfgang Roether

doi:10.1038/nature05832

See also: Editor's summary


The depth distribution of azimuthal anisotropy in the continental upper mantle p198

Federica Marone & Barbara Romanowicz

doi:10.1038/nature05742


Sexual dimorphism and adaptive radiation in Anolis lizards p202

Marguerite A. Butler, Stanley A. Sawyer & Jonathan B. Losos

doi:10.1038/nature05774

See also: Editor's summary


Image statistics and the perception of surface qualities p206

Isamu Motoyoshi, Shin'ya Nishida, Lavanya Sharan & Edward H. Adelson

doi:10.1038/nature05724

See also: Editor's summary | News and Views by Landy


Maintaining a behaviour polymorphism by frequency-dependent selection on a single gene p210

Mark J. Fitzpatrick, Elah Feder, Locke Rowe & Marla B. Sokolowski

doi:10.1038/nature05764

See also: Editor's summary


A chromatin link that couples cell division to root epidermis patterning in Arabidopsis p213

Elena Caro, M. Mar Castellano & Crisanto Gutierrez

doi:10.1038/nature05763


The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex p218

Travis H. Stracker, Monica Morales, Suzana S. Couto, Hussein Hussein & John H. J. Petrini

doi:10.1038/nature05740


The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs p222

Stefan Weitzer & Javier Martinez

doi:10.1038/nature05777

See also: News and Views by Trotta


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Naturejobs

Prospect

Writing has a crucial role in many different scientific pursuits p227

Paul Smaglik

doi:10.1038/nj7141-227a


Career Views

Pier Paolo Pandolfi, Director, Cancer Genetics Programme, Beth Israel Deaconess Medical Center, Harvard University p228

Cancer geneticist leaves Sloan Kettering for Harvard

Virginia Gewin

doi:10.1038/nj7141-228a


Earth network p228

Young scientists come together to tackle the complexities of climate change

Marko Scholze

doi:10.1038/nj7141-228b


Worst and best of times p228

Starting a completely new project has been just as daunting as I'd expected

Chris Rowan

doi:10.1038/nj7141-228c


Recruiters

The evolution of life-sciences sales p230

In the age of e-commerce, sales reps must give more than just information: they must be trusted advisers.

Tamara Zemlo

doi:10.1038/nj7141-230a


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