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News and Views
Nature 447, 42-43 (3 May 2007) | doi:10.1038/nature05715; Published online 22 April 2007
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Chemical Biology: Ignore the nonsense
Anton Schmitz1 & Michael Famulok1
Abstract
A small molecule forces the protein-translation machinery to overlook the signals that would otherwise result in its premature termination. Genuine stop signs are, however, read and obeyed.
Several inherited diseases are caused by mutations in single nucleotides within genes. These mutations can transform the products of messenger RNA codons, the sets of three nucleotides that determine which amino acid is incorporated into the growing protein chain.
- Anton Schmitz and Michael Famulok are at the LIMES Institute, Program Unit Chemical Biology and Medicinal Chemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.
Email: m.famulok@uni-bonn.de
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