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Chemical biology

Dressed-up proteins

Proteins aren't just defined by their constituent amino acids — structural modifications can yield complex mixtures of protein forms. An approach that controls the addition of such modifications may help to define their role.

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Figure 1: Dressing up proteins.

References

  1. Van Kasteren, S. I. et al. Nature 446, 1105–1109 (2007).

    Article  ADS  CAS  Google Scholar 

  2. Simon, M. D. et al. Cell 128, 1003–1012 (2007).

    Article  CAS  Google Scholar 

  3. Rostovtsev, V. V., Green, L. G., Fokin, V. V. & Sharpless, K. B. Angew. Chem. Int. Edn 41, 2596–2599 (2002).

    Article  CAS  Google Scholar 

  4. Tornoe, C. W., Christensen, C. & Meldal, M. J. Org. Chem. 67, 3057–3064 (2002).

    Article  CAS  Google Scholar 

  5. Saxon, E. & Bertozzi, C. R. Science 287, 2007–2010 (2000).

    Article  ADS  CAS  Google Scholar 

  6. Kiick, K. L., Saxon, E., Tirrell, D. A. & Bertozzi, C. R. Proc. Natl Acad. Sci. USA 99, 19–24 (2002).

    Article  ADS  CAS  Google Scholar 

  7. Fazio, F. et al. J. Am. Chem. Soc. 124, 14397–14402 (2002).

    Article  CAS  Google Scholar 

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Grotenbreg, G., Ploegh, H. Dressed-up proteins. Nature 446, 994–995 (2007). https://doi.org/10.1038/446993a

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