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Volume 446 Issue 7137, 12 April 2007

Editorial

  • Poor nations need the data that show what is already happening to their climate, as well as the resources with which to adapt to change.

    Editorial

    Advertisement

  • Researchers should push for rule changes to make Europe work as one.

    Editorial
  • Government scientists should be able to comment publicly — within reason.

    Editorial
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Research Highlights

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News

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News in Brief

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Correction

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Column

  • The US National Science Foundation may soon have to supply lab equipment to poverty-stricken high schools. David Goldston explains why some politicians want the agency to pay for Bunsen burners and test-tubes.

    • David Goldston
    Column
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Business

  • Car companies know that plastic parts made from plants will appeal to 'green' customers. But as Ichiko Fuyuno reports, their progress has been painfully slow.

    Business
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News Feature

  • African communities have been adapting to climate change for millennia. Jim Giles reports on the strategies that seem most effective.

    • Jim Giles
    News Feature
  • Despite years of speculation, little can be said for sure about the future of the Arctic's permafrost. But that's no grounds for complacency, reports Gabrielle Walker.

    • Gabrielle Walker
    News Feature
  • Members of the public are taking to the streets to spread Al Gore's message of climate crisis. Amanda Haag meets the foot soldiers of global warming.

    • Amanda Haag
    News Feature
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Correspondence

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Commentary

  • Carbon sinks play a key role in slowing the growth of carbon dioxide levels in the atmosphere. These sinks are at risk as the world warms, but their demise is not inevitable, say Dave Reay and his colleagues.

    • Dave Reay
    • Christopher Sabine
    • Graham Hymus
    Commentary
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Books & Arts

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Connections

  • Understanding the dynamics of infectious-disease transmission demands a holistic approach, yet today's models largely ignore how epidemics change individual behaviour.

    • Neil Ferguson
    Connections
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News & Views

  • Some genes are involved in the development of a new tumour; others specifically promote the dissemination of its cancerous cells to other organs. A set of four genes seems to be required for both processes.

    • Gerhard Christofori
    News & Views
  • The idea of bendy crystals, especially ones that move rapidly and reversibly in response to light, seems strange. Such materials have now been prepared — but how do they change shape so dramatically without cracking?

    • J. Michael McBride
    News & Views
  • Genomic characterization of a type of leukaemia has resulted in the identification of common genetic abnormalities that underlie the disease. The results constitute an advance on several fronts.

    • Todd R. Golub
    News & Views
  • Knowing how plants and bacteria harvest light for photosynthesis so efficiently could provide a clean solution to mankind's energy requirements. The secret, it seems, may be the coherent application of quantum principles.

    • Roseanne J. Sension
    News & Views
  • A popular route for protein transport into and across cell membranes is through the Sec channel. This channel seems to function by forming a dimer of two identical units, where each has a distinct role.

    • Franck Duong
    News & Views
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News and Views Q&A

  • Autophagy is the degradation of redundant or faulty cell components. It occurs as part of a cell's everyday activities and as a response to stressful stimuli, such as starvation. Connections with cellular life-and-death decisions and with cancer are now emerging.

    • Beth Levine
    News and Views Q&A
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Review Article

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Article

  • A genome-wide, high-resolution single nucleotide polymorphism array analysis of a large number of acute lymphoblastic leukaemia samples identifies a number of genomic changes. These include alterations in the genes encoding Pax5 and other regulators of B-cell development and differentiation.

    • Charles G. Mullighan
    • Salil Goorha
    • James R. Downing
    Article
  • Previous studies identified genes involved in tissue-specific metastasis of breast cancer cells to the lung. New work now shows how four of these genes cooperate to remodel the vasculature and thereby both tumour cell intravasation into the circulation and extravasation of blood vessels in the lung to form metastases.

    • Gaorav P. Gupta
    • Don X. Nguyen
    • Joan Massagué
    Article
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Letter

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Corrigendum

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Addendum

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Prospects

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Careers and Recruitment

  • Just a decade has changed cancer research beyond recognition, but adaptable skills and teamwork lead to exciting possibilities. Ricki Lewis looks at the new face of cancer genetics.

    • Ricki Lewis
    Careers and Recruitment
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Movers

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Networks and Support

  • Fellow finds interdicisplinary options.

    • Giovanni Frazzetto
    Networks and Support
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Career View

  • Postdoc adapting to new minutae in South Africa.

    • Chris Rowan
    Career View
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Recruiters

  • Let's talk money: what you're likely to earn, how to get a pay rise and when to consider other options.

    • Martin Lang
    Recruiters
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Authors

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