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Nature 446, 499-500 (29 March 2007) | doi:10.1038/446499a; Published online 28 March 2007
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Canada Research Chair (Tier 1) Alfred Bader Chair in Organic Chemistry
- Queens University
- Kingston, ON, Canada
Food Chemist & Bioactive Specialist
- Nestle Research Center
- Lausanne Switzerland
Chemical biology: A degrading solution to pollution
J. Wade Harper1
Abstract
Environmental pollutants such as dioxins affect human health. It now seems that dioxins exert their effect by forming atypical enzyme complexes that mediate the breakdown of steroid-hormone receptors.
Dioxins are some of the most prevalent and dangerous pollutants in the environment. They are generated as by-products of, among other things, rubbish incineration and industrial processes1, and act by disrupting the endocrine system.
- J. Wade Harper is in the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Email: wade_harper@hms.harvard.edu
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Dioxin receptor is a ligand-dependent E3 ubiquitin ligaseNature Letters to Editor (29 Mar 2007)
