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Nature 446, 274-275 (15 March 2007) | doi:10.1038/446274a; Published online 14 March 2007
There is a Correction (19 April 2007) associated with this document.
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Cell biology: Lost in mitotic translation
Anthony Wynshaw-Boris1
Abstract
A protein called 14-3-3
inhibits the cell cycle and may act as a tumour suppressor. It now turns out that it is also involved in regulating protein synthesis from messenger RNA during cell division.
Movement through the cell cycle is regulated by structural modification of proteins after they have been translated from messenger RNA (mRNA). Such changes are known to be important in regulating DNA checkpoint and repair pathways, in triggering cell division (mitosis) and in maintaining the mitotic spindle, which ensures that the chromosomes separate correctly.
- Anthony Wynshaw-Boris is in the Departments of Pediatrics and Medicine, Center for Human Genetics and Genomics, University of California, San Diego, La Jolla, California 92093-0627, USA.Email: awynshawboris@ucsd.edu
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RESEARCH
14-3-3&sgr; controls mitotic translation to facilitate cytokinesisNature Letters to Editor (15 Mar 2007)
A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosisThe EMBO Journal Article (10 Jan 2007)
cdc2?cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent mannerThe EMBO Journal Article (09 Apr 2008)
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