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Nature 446, 145-146 (8 March 2007) | doi:10.1038/446145a; Published online 7 March 2007
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Executive Director & Deans
- Translational Health Science and Technology Institute (THSTI); C / o National Institute of Immunology
- Delhi 110067 India
University Full-Professor (W3, Tenure Track)
- University of Münster
- Munster 48149 Germany
Cancer: Drivers and passengers
Daniel A. Haber1 & Jeff Settleman1
Abstract
Studies that have provided the first unbiased, large-scale analyses of DNA mutations across an array of cancers also have lessons for the proposal to annotate the entire cancer genome.
Cancer results from an accumulation of mutations and other heritable changes in susceptible cells. So far, abnormalities in about 350 genes have been implicated in human cancers, but the true number of 'cancer genes' is unknown.
- Daniel A. Haber and Jeff Settleman are at the Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149–7, Charlestown, Massachusetts 02129, USA.
Email: haber@helix.mgh.harvard.edu
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