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Nature 445, 724-726 (15 February 2007) | doi:10.1038/445724a; Published online 14 February 2007
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Developmental biology: Cell fate in the mammary gland
Qiang Tong1 & Gökhan S. Hotamisligil2
Abstract
Most breast cancers have their origin in the luminal epithelial cells of the mammary gland. Defining how a master regulator controls the development of this cell lineage could provide important hints about why this should be.
The developmental biology of the mammary gland is a fascinating process — from its origins in the embryo to the many dynamic changes in later stages of life. But it is thought to be perverted in breast cancer.
- Qiang Tong is in the USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Email: qtong@bcm.tmc.edu - Gökhan S. Hotamisligil is in the Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Email: ghotamis@hsph.harvard.edu
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GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasisOncogene Original Article
β1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cellsNature Cell Biology Letter (01 Jun 2008)
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