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Nature 445, 575 (8 February 2007) | doi:10.1038/445575a; Published online 7 February 2007

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Virus paper reignites prion spat

Heidi Ledford

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Neuroscientist challenges conventional wisdom on brain disease.

Mention the name Laura Manuelidis to a prion researcher, and you will almost certainly get a strong reaction. For years the Yale University neuropathologist has ruffled feathers by arguing that a virus causes neurological conditions such as Creutzfeldt–Jakob disease in humans and scrapie in animals, rather than an infectious protein, or 'prion', as most researchers believe.

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