Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cell biology

A switch for S phase

DNA replication is a necessary prelude to the division of a eukaryotic cell. Initiation of this process requires a complex script, involving many proteins: details of one of the main acts now emerge.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: DNA replication and the switch from G1 to S phase.

References

  1. Li, J. J. & Alberts, B. Nature 357, 114–115 (1992).

    Article  ADS  CAS  Google Scholar 

  2. Bell, S. P. & Stillman, B. Nature 357, 128–134 (1992).

    Article  ADS  CAS  Google Scholar 

  3. Zegerman, P. & Diffley, J. F. X. Nature 445, 281–285 (2007).

    Article  ADS  CAS  Google Scholar 

  4. Tanaka, S. et al. Nature 445, 328–332 (2007).

    Article  ADS  CAS  Google Scholar 

  5. Randell, J. C. W., Bowers, J. L., Rodriguez, H. K. & Bell, S. P. Mol. Cell 21, 29–39 (2006).

    Article  CAS  Google Scholar 

  6. Blow, J. J. & Dutta, A. Nature Rev. Mol. Cell Biol. 6, 476–486 (2005).

    Article  CAS  Google Scholar 

  7. Sheu, Y. J. & Stillman, B. Mol. Cell 24, 101–113 (2006).

    Article  CAS  Google Scholar 

  8. Kanemaki, M. & Labib, K. EMBO J. 25, 1753–1763 (2006).

    Article  CAS  Google Scholar 

  9. Moyer, S. E., Lewis, P. W. & Botchan, M. R. Proc. Natl Acad. Sci. USA 103, 10236–10241 (2006).

    Article  ADS  CAS  Google Scholar 

  10. Pacek, M. et al. Mol. Cell 21, 581–587 (2006).

    Article  CAS  Google Scholar 

  11. Gambus, A. et al. Nature Cell Biol. 8, 358–366 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Botchan, M. A switch for S phase. Nature 445, 272–273 (2007). https://doi.org/10.1038/445272a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/445272a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing