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Nature 444, 831-832 (14 December 2006) | doi:10.1038/444831a; Published online 13 December 2006

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Neurobiology: A channel sets the gain on pain

Stephen G. Waxman1

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Nerve impulses that convey pain signals to the brain are produced by sodium channels in the neuronal membrane. Studies on people who are unable to feel pain identify one specific sodium channel as essential to the process.

"God...shouts in our pain. It is his megaphone..."— C.

  1. Stephen G. Waxman is in the Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA and the Center for Neuroscience and Regeneration Research, VA Hospital, West Haven, Connecticut.
    Email: stephen.waxman@yale.edu

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