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News and Views
Nature 444, 429-431 (23 November 2006) | doi:10.1038/444429a; Published online 22 November 2006
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Postdoctoral Position, Endocrine Unit
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Cell biology: Infectious Alzheimer's disease?
Roland Riek1
Abstract
Accumulation of organized, self-polymerizing protein aggregates is a hallmark of Alzheimer's disease and infectious prion diseases. The similarities between these conditions may be even closer than that.
Amyloid fibrils are malicious. These insoluble, highly organized protein aggregates are associated with devastating disorders such as Alzheimer's and Parkinson's diseases, type II diabetes and the prion (proteinaceous infectious particle) diseases that include Creutzfeldt–Jakob and mad cow diseases1.
- Roland Riek is in the Department of Structural Biology, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Email: riek@salk.edu
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