Supplementary information

From the following article:

Analysis of one million base pairs of Neanderthal DNA

Richard E. Green, Johannes Krause, Susan E. Ptak, Adrian W. Briggs, Michael T. Ronan, Jan F. Simons, Lei Du, Michael Egholm, Jonathan M. Rothberg, Maja Paunovic & Svante Pääbo

Nature 444, 330-336(16 November 2006)

doi:10.1038/nature05336

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Supplementary Notes

This file contains the Supplementary Methods, Supplementary Results, Supplementary Tables 1–3 and Supplementary Figures 1–6.

Supplementary Data 1

This file contains the results of single-linkage clustering of all Neanderthal extract sequences. Each line contains the identifier(s) of the sequences in that cluster. Sequences were clustered by 95% identity over 95% of their length, as described in Supplementary Methods.

Supplementary Data 2

This file contains a tab-delimited text table with best database hit information for each sequence. There are fields for the best hit sequence ID, organism, and various alignment statistics, including the alignment strings.

Supplementary Data 3

Master alignment in fasta alignment format of complete mtDNA sequences from 311 humans, 3 chimpanzees, 2 bonobos, and 1 gorilla. This is the alignment into which the Neanderthal mtDNA sequences were merged.

Supplementary Data 4

Alignment file of Neanderthal mtDNA sequence fragments merged into the master alignment, in clustalw format. Note that the mtDNA phylogenetic analysis does not include the gorilla sequence.

Supplementary Data 5

Alignment file of Neandertal mtDNA sequences that were PCR confirmed from the original extract, in clustalw format. Note that the mtDNA phylogenetic analysis does not include the gorilla sequence.

Supplementary Data 7

3-way multiple sequence alignment of Neanderthal/human/chimpanzee sequences with chimpanzee quality-score codes, in fasta-like format.

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