FIGURE 3. Sweet, umami, bitter and sour are mediated by specific receptors and cells.

From the following article:

The receptors and cells for mammalian taste

Jayaram Chandrashekar, Mark A. Hoon, Nicholas J. P. Ryba & Charles S. Zuker

Nature 444, 288-294(16 November 2006)

doi:10.1038/nature05401

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The traces show recordings of tastant-induced activity in nerves innervating the tongue in wild-type and various gene-knockout (KO) mice or cell ablation studies (Pkd2l1-DTA). T1R1+3 functions as the umami receptor, T1R2+3 is the sweet receptor, T2Rs are bitter receptors (T2R5 is a high-affinity cycloheximide receptor), PKD2L1 is a candidate sour receptor, and PLC-beta2 is the effector and TRPM5 the transduction channel of sweet, umami and bitter pathways. Note the extraordinarily specific taste deficits (red traces) in each genetically altered mouse line. Pkd2l1-DTA refers to animals expressing diphtheria toxin in PKD2L1 cells.

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