Supplementary information

From the following article:

Inactivation of the p53 pathway in retinoblastoma

Nikia A. Laurie, Stacy L. Donovan, Chie-Schin Shih, Jiakun Zhang, Nicholas Mills, Christine Fuller, Amina Teunisse, Suzanne Lam, Yolande Ramos, Adithi Mohan, Dianna Johnson, Matthew Wilson, Carlos Rodriguez-Galindo, Micaela Quarto, Sarah Francoz, Susan M. Mendrysa, R. Kiplin Guy, Jean-Christophe Marine, Aart G. Jochemsen & Michael A. Dyer

Nature 444, 61-66(2 November 2006)

doi:10.1038/nature05194

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Supplementary Notes

This file contains Supplementary Tables 1–8, Supplementary Figures 1–10 and detailed Supplementary Methods. The Supplementary Tables present data from dissociated cell scoring, FISH analysis and clone size analysis of MDM2Lox/Lox MEFs. The Supplementary Figures provide additional data on modulation of the p53 pathway by MDM2 and MDMX in normal and transformed cells. The figures also provide additional data on the mechanism of topotecan and nutlin-3 mediated killing of retinoblastoma cells and cell-based assays demonstrating that nutlin-3 can kill Mdm2-deficient MEFs by binding to MdmX. The Supplementary Methods provide details about antibodies, cDNAs, siRNAs, microscopy, retinoblastoma tissue analysis, statistical analysis, protein purification and nutlin-3 binding studies and MEF experiments.

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