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Brief Communications
Nature 443, 159 (14 September 2006) | doi:10.1038/443159a; Received 1 August 2006; Accepted 22 August 2006; Published online 13 September 2006
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Tumour biology: Policing of oncogene activity by p53
Alejo Efeyan1, Isabel Garcia-Cao1, Daniel Herranz1, Susana Velasco-Miguel1 & Manuel Serrano1
Abstract
Oncogenes, rather than DNA damage, may provide the key signal to p53 to trigger tumour suppression.
Abstract
The tumour-suppressor protein p53 provides the most important genetic defence against cancer1 and is activated in response to DNA damage and to oncogenic signalling, both of which occur almost universally in malignant tumours. But the relative contribution of these two pathways in inducing p53-dependent protection against cancer is unclear. Here we show that p53-dependent protection against cancer is lost in mice that have been genetically manipulated so that their p53 is activated in response to DNA damage but not to oncogenic signalling. We conclude that oncogenic signalling is the critical event that elicits p53-dependent protection and that the DNA-damage stimulus is less important.
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Cancer biology Can less be more for p53?Nature News and Views (14 Sep 2006)
Tumour suppression: something for nothing?Nature Cell Biology News and Views (01 Dec 2002)
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