FIGURE 5. Schematic illustration of the proposed 'functionally rotating ordered multidrug binding change mechanism' mediated by AcrB.
From the following article:
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Satoshi Murakami, Ryosuke Nakashima, Eiki Yamashita, Takashi Matsumoto and Akihito Yamaguchi
Nature 443, 173-179(14 September 2006)
doi:10.1038/nature05076
a, The top view from the distal side of the cell. Colours and arrangements in the left panel correspond to those in Fig. 1. b, The view from the side parallel to the membrane plane. For a, b, the entrance and exit sites within each protomer are depicted as red flaps. The drug binding pocket and translocation pathway are represented by dotted lines. Drugs are illustrated as hexagons.
