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News and Views
Nature 443, 37-38 (7 September 2006) | doi:10.1038/nature05003; Published online 16 August 2006
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A proposal for stable expression of an enzyme in corn seed is desired.
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Beamline Scientist PROXIMA 2
- Synchrotron Soleil
- Gif Sur Yvette 91190 France
Postdoctoral Researcher
- Harvard University School of Public Health
- Boston, MA
Structural biology: Antiviral drugs fit for a purpose
Ming Luo1
Abstract
Did drug researchers have a lucky break when they developed antiviral drugs for influenza? Crystal structures of enzymes from the H5N1 virus suggest that they did, and provide avenues for further exploration.
Oseltamivir (Tamiflu) and zanamivir (Relenza) have been stockpiled by several nations to counter the threat of a flu pandemic, should the highly pathogenic avian influenza virus H5N1 develop into a human strain. These drugs are inhibitors of an enzyme known as neuraminidase, which is found on the surface of the flu virus.
- Ming Luo is in the Department of Microbiology, University of Alabama, Birmingham, 1025 18th Street South, Birmingham, Alabama 35294, USA.
Email: mingluo@uab.edu
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