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Nature 443, 35-36 (7 September 2006) | doi:10.1038/443035a; Published online 6 September 2006
Cancer biology: Infectious tumour cells
David Dingli1 & Martin A. Nowak1
Abstract
Cancer cells are generally viewed as a problem innate to their host, but evidence is mounting that they can evolve to become infectious agents and be transmitted between individuals.
The current view of cancer development is that normal cells are transformed into tumour cells by sequential mutations that activate cancer-promoting 'oncogenes', or inhibit genes that would otherwise suppress tumours, or trigger genetic instabilities. As a consequence, every tumour is the result of a unique evolutionary process as the cancer cells adapt to out-compete their neighbours.
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