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Nature 442, 991-992 (31 August 2006) | doi:10.1038/nature05173; Published online 23 August 2006
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Cell biology: Taking a turn into the nucleus
Ulrike Kutay1 & Petra Mühlhäusser1
Abstract
How soluble proteins get into the cell nucleus is known in great detail, but how membrane proteins make it into the inner nuclear membrane has long been an enigma. The two processes in fact turn out to be related.
Eukaryotic cells house their genome in a dedicated intracellular compartment — the cell nucleus. The boundary of this organelle is a double lipid bilayer termed the nuclear envelope, which consists of an outer nuclear membrane (ONM) that is continuous with the membrane system of the endoplasmic reticulum (ER), and an inner nuclear membrane (INM) of a different protein composition.
- Ulrike Kutay and Petra Mühlhäusser are at the Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland.
Email: ulrike.kutay@bc.biol.ethz.ch
Email: petra.muehlhaeusser@bc.biol.ethz.ch
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