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Nature 442, 510 (3 August 2006) | doi:10.1038/442510c; Published online 2 August 2006

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Bias was built into research from the beginning

Margaret M. McCarthy1

  1. Departments of Physiology and Psychiatry, University of Maryland Baltimore School of Medicine, 655 W. Baltimore Street, Baltimore Maryland 21201, USA

As a basic scientist attempting to understand the mechanistic basis of sex differences in the brain, I found Ben Barres's Commentary article1 of particular interest.The existence of robust and reliable sex differences in brain regions relevant to the control of reproduction cannot be refuted.