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Nature 442, E3-E4 (13 July 2006) | doi:10.1038/nature04907; Published online 12 July 2006
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Embryology: Does prepatterning occur in the mouse egg?
Takashi Hiiragi1, Sophie Louvet-Vallée2, Davor Solter1 & Bernard Maro2,3
Abstract
Arising from: B. Plusa et al. Nature 434, 391–395 (2005); Plusa et al. reply
A recurring question in developmental biology has been whether localized determinants play any role in mammalian preimplantation development1. This is a controversial issue that brings back the idea of prepatterning2, 3, 4 and is explored further by Plusa et al.5, who claim it is the first cleavage of the mouse zygote that predicts the blastocyst axis, rather than the animal pole or sperm entry point, as previously suggested3. However, other evidence indicates that the blasotcyst axis is not predetermined and there is no prepatterning in the mouse egg6, 7, 8, 9, 10, 11, 12. Here we investigate the origin of these different views and conclude that they arise from differences in the data themselves and in their interpretation.
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RESEARCH
Embryology Does prepatterning occur in the mouse egg? (Reply)Nature Brief Communication (13 Jul 2006)
The first cleavage of the mouse zygote predicts the blastocyst axisNature Letters to Editor (17 Mar 2005)
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