Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 441, 1058 (29 June 2006) | doi:10.1038/4411058a; Published online 28 June 2006
Open Innovation Challenges
-
Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
-
Direct Molecular Detection of Proteins and Nucleic Acids
This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id...
- More Challenges
- Powered by:
nature jobs
Gastroenterologists
- Gastroenterology Consultants, SC
- Moline, Illinois, USA
Academic Surgical Pathologists
- Northwestern University
- Chicago, Illinois, USA
Neurodegenerative disease: Pink, parkin and the brain
Leo Pallanck1 & J. Timothy Greenamyre2
Abstract
Dysfunctions in a number of cellular pathways can cause Parkinson's disease. Fruitflies with mutations in a protein called PINK1 show that there might be some unsuspected interplay between two such pathways.
Parkinson's disease was first described1 in 1817, but our understanding of what causes the neurodegeneration that underlies its devastating symptoms is still rudimentary. Such poor understanding hinders the development of therapies, which currently don't seem to modify disease progression, even if they can mitigate for a time some of the movement difficulties that characterize this condition.
- Leo Pallanck is in the Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
Email: pallancku.washington.edu - J. Timothy Greenamyre is at the Pittsburgh Institute for Neurodegenerative Diseases and the Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
HtrA2 and Parkinson's disease: think PINK?Nature Cell Biology News and Views (01 Nov 2007)
Parkinson's disease Pro-survival effects of PINK1Nature News and Views (16 Aug 2007)
See all 3 matches for News And ViewsRESEARCH
DJ-1 and Parkin Modulate Dopamine-dependent Behavior and Inhibit MPTP-induced Nigral Dopamine Neuron Loss in MiceMolecular Therapy Original Article
14-3-3η is a novel regulator of parkin ubiquitin ligaseThe EMBO Journal Article (11 Jan 2006)
See all 11 matches for Research