Supplementary information

From the following article:

Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise

John R. S. Newman, Sina Ghaemmaghami, Jan Ihmels, David K. Breslow, Matthew Noble, Joseph L. DeRisi and Jonathan S. Weissman

Nature 441, 840-846(15 June 2006)

doi:10.1038/nature04785

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Supplementary Notes 1

Instruction manual for custom software described in the main text. Instructions on how to use 'HTSPro' to control the delivery of samples to a flow cytometer, as well as to control the software that runs the cytometer. As noted in the Supplementary Text, the software is available to academic users from the Authors.

Supplementary Notes 2

Supplementary information about experimental design, execution and interpretation. Also provided is a supplementary discussion and supplementary figures that support the Main Text.

Supplementary Table 1

Abundance and variation measurements for strains grown in YEPD and SD.

Supplementary Table 2

Supplementary Table 2 nature04785-s04.xls Changes in protein and mRNA levels for strains grown in YEPD and SD.

Supplementary Table 3

Statistics for calculating the number of false positive and false negative strains.

Supplementary Table 4

Primers Used for Tagging and Deletion of ORFs

Supplementary Table 5

Organization of GO-Term, transcription factor and transcription module correlations associated with low or high variation

Supplementary Table 6

References for data used for P-value calculations

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