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Nature 441, 817-818 (15 June 2006) | doi:10.1038/441817a; Published online 14 June 2006
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Structural biology: Images from the surface of HIV
Dennis R. Burton1
Abstract
Human and monkey immunodeficiency viruses are studded with 'spikes' that enable them to infect cells. Structural studies reveal that these spikes are tripod-like assemblies that cluster on the virus surface.
Newly produced HIV particles are in limbo between life and death, their fate determined by whether protruding structures — 'spikes' — on their surface make contact with receptors on the surface of white blood cells, in particular a subset known as CD4+ T cells. If a productive contact is made, a molecular sequence is triggered that results in the genetic material of the virus being injected into the target cell.
- Dennis R. Burton is in the Departments of Immunology and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Email: burton@scripps.edu
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RESEARCH
Distribution and three-dimensional structure of AIDS virus envelope spikesNature Article (15 Jun 2006)
Restraining the conformation of HIV-1 gp120 by removing a flexible loopThe EMBO Journal Article (18 Oct 2006)
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibodyNature Article (18 Jun 1998)
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