Access
To read this story in full you will need to login or make a payment (see right).
Insight
Nature 441, 444-450 (25 May 2006) | doi:10.1038/nature04872; Published online 24 May 2006
Review article New signals from the invasive front
Gerhard Christofori1
Abstract
Approximately 90% of all cancer deaths arise from the metastatic spread of primary tumours. Of all the processes involved in carcinogenesis, local invasion and the formation of metastases are clinically the most relevant, but they are the least well understood at the molecular level. Revealing their mechanisms is one of the main challenges for exploratory and applied cancer research. Recent experimental progress has identified a number of molecular pathways and cellular mechanisms that underlie the multistage process of metastasis formation: these include tumour invasion, tumour-cell dissemination through the bloodstream or the lymphatic system, colonization of distant organs and, finally, fatal outgrowth of metastases.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
TCR avidity: it's not how strong you make it, it's how you make it strongNature Immunology News and Views (01 Aug 2001)
GSK-3β sets Snail's paceNature Cell Biology News and Views (01 Oct 2004)
The fatal detachmentNature Cell Biology News and Views (01 Jul 2001)
