Access
To read this story in full you will need to login or make a payment (see right).
Insight
Nature 441, 437-443 (25 May 2006) | doi:10.1038/nature04871; Published online 24 May 2006
Review article Hypoxia signalling in cancer and approaches to enforce tumour regression
Jacques Pouysségur1, Frédéric Dayan1 & Nathalie M. Mazure1
Abstract
Tumour cells emerge as a result of genetic alteration of signal circuitries promoting cell growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is central in controlling neovascularization, glucose metabolism, survival and tumour spread. This pleiotropic action is orchestrated by hypoxia-inducible factor (HIF), which is a master transcriptional factor in nutrient stress signalling. Understanding the role of HIF in intracellular pH (pHi) regulation, metabolism, cell invasion, autophagy and cell death is crucial for developing novel anticancer therapies. There are new approaches to enforce necrotic cell death and tumour regression by targeting tumour metabolism and pHi-control systems.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
HIF, a missing link between metabolism and cancerNature Medicine News and Views (01 Oct 2005)
Masters of angiogenesisNature Medicine News and Views (01 Sep 2005)
Targeting tumors through the HIF systemNature Medicine News and Views (01 Dec 2000)