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Nature 441, 431-436 (25 May 2006) | doi:10.1038/nature04870; Published online 24 May 2006
Review article Nuclear factor-
B in cancer development and progression
Michael Karin1
Abstract
Nuclear factor-
B (NF-B) transcription factors and the signalling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-B signalling also has a critical role in cancer development and progression. NF-B provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. NF-B might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches.
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