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Nature 441, 296-297 (18 May 2006) | doi:10.1038/441296a; Published online 17 May 2006
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Cell biology: Skin care by keratins
Abstract
Keratin proteins perform several functions in skin cells, including those of providing mechanical support and protection against injury. But it seems they also have a more active part to play in healing wounds.
Like the musculoskeletal framework of humans or the steel-girder scaffolds of buildings, the intermediate filaments of the cytoskeleton shield cells from mechanical forms of injury1, 2, 3. Intermediate filaments are made up of a large family of tissue-specific proteins, including desmin in muscle, neurofilaments in neurons and keratins in the epithelial cells that line organs such as the skin1, 2, 3.
- M. Bishr Omary and Nam-On Ku are in the Department of Medicine, VA Palo Alto Health Care System and Stanford University School of Medicine, 3801 Miranda Avenue, Mail code 154J, Palo Alto, California 94304, USA.
Email: mbishr@stanford.edu
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RESEARCH
A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growthNature Letters to Editor (18 May 2006)
Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethalityThe EMBO Journal Article (02 Oct 2000)
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