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Nature 441, 296-297 (18 May 2006) | doi:10.1038/441296a; Published online 17 May 2006
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Cell biology: Skin care by keratins
Abstract
Keratin proteins perform several functions in skin cells, including those of providing mechanical support and protection against injury. But it seems they also have a more active part to play in healing wounds.
Like the musculoskeletal framework of humans or the steel-girder scaffolds of buildings, the intermediate filaments of the cytoskeleton shield cells from mechanical forms of injury1, 2, 3. Intermediate filaments are made up of a large family of tissue-specific proteins, including desmin in muscle, neurofilaments in neurons and keratins in the epithelial cells that line organs such as the skin1, 2, 3.
- M. Bishr Omary and Nam-On Ku are in the Department of Medicine, VA Palo Alto Health Care System and Stanford University School of Medicine, 3801 Miranda Avenue, Mail code 154J, Palo Alto, California 94304, USA.
Email: mbishr@stanford.edu
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RESEARCH
Pyridoxamine lowers kidney crystals in experimental hyperoxaluria: A potential therapy for primary hyperoxaluriaKidney International Original Article
A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growthNature Letters to Editor (18 May 2006)
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