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Nature 441, 289 (18 May 2006) | doi:10.1038/441289a; Published online 17 May 2006

Concept Time for a change

Norman R. Pace1

  1. Norman R. Pace is in the Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347, USA.
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Prokaryote: gene-sequence comparisons show the tree of life consists of bacteria, eukarya and archaea. The use of the term 'prokaryote' fails to recognize that an idea about life's origins has been proved wrong.

The explosive accumulation of gene sequences over the past few decades has brought a new perspective on life and its history. Some of the results indicate that we need to reassess our understanding of the course of evolution at the most fundamental level.