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Nature 441, 35-37 (4 May 2006) | doi:10.1038/441035a; Published online 3 May 2006
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Full-Professor of Heart and Thoracic Surgery (W3) (f / m)
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Molecular biology: Chromosome guardians on duty
Paul Megee1
Abstract
Curiously, in cell division the proper separation of chromosomes into daughter cells needs set periods when they are stuck together. So how do they come apart at the right time and place? Their 'guardian spirits' intercede.
To avoid cell death or genetic diseases such as cancer, chromosomes must be transmitted to progeny cells with high fidelity. During cell division, chromosomes are duplicated to form sister chromatids, which must then be divided into two equal groups and separated into daughter cells (a process termed segregation).
- Paul Megee is in the Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Mail Stop 8101, PO Box 6511, Aurora, Colorado 80045, USA.
Email: paul.megee@uchsc.edu
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