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Nature 440, 1121-1122 (27 April 2006) | doi:10.1038/4401121a; Published online 26 April 2006
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Manager Medical Writitng
- Indegene Lifesystems Pvt. Ltd
- Bengaluru 560 071 India
Postdoctoral Associate in Enzyme Biochemistry
- Cornell University
- Ithaca, New York
Molecular biology: Singled out for integration
Michael Chandler1
Abstract
Bacteria regularly swap genes among themselves. The structure of an enzyme that mediates the spread of certain DNA elements reveals the unusual way in which they take up residence in new genomes.
The transfer of genes among bacteria is crucial in generating diversity, allowing bacteria to adapt quickly to changing environments. Mobile DNA elements called integron cassettes are major vehicles in such gene exchange.
- Michael Chandler is at the Laboratoire de Microbiologie et Génétique Moléculaire (CNRS, UMR5100), Campus Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France.
Email: mike@ibcg.biotoul.fr
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RESEARCH
Structural basis for broad DNA-specificity in integron recombinationNature Article (27 Apr 2006)
Integron cassette insertion: a recombination process involving a folded single strand substrateThe EMBO Journal Article (21 Dec 2005)
What are superintegrons?Nature Reviews Microbiology Correspondence (01 Feb 2007)
